Common Name: Diepoxybutane
CAS Number: 1464-53-5
DOT Number: NA 1955
DATE: June, 1989
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HAZARD SUMMARY
* Diepoxybutane can effect you when breathed in and may be
absorbed through the skin.
* Diepoxybutane should be handled as a CARCINOGEN--WITH EXTREME
CAUTION.
* Contact can severely irritate and burn the eyes with possible
permanent damage.
* Diepoxybutane can severely irritate and burn the skin with
blistering.
* Breathing Diepoxybutane can irritate the nose, throat and
lungs causing a cough. Higher exposure may cause a build-up
of fluid in the lungs (pulmonary edema), a medical emergency.
* Repeated exposure may cause liver damage.
IDENTIFICATION
Diepoxybutane is a colorless liquid or a solid. It is used as a
curing agent or hardener for polymer resins, and for making
synthetic textile fibers.
REASON FOR CITATION
* Diepoxybutane is on the Hazardous Substance List because it is
cited by DOT, NTP, IARC and EPA.
* This chemical is on the Special Health Hazard Substance List
because it is a CARCINOGEN.
HOW TO DETERMINE IF YOU ARE BEING EXPOSED
* Exposure to hazardous substances should be routinely
evaluated. This may include collecting personal and area air
samples. You can obtain copies of sampling results from your
employer. You have a legal right to this information under
OSHA 1910.20.
* If you think you are experiencing any work-related health
problems, see a doctor trained to recognize occupational
diseases. Take this Fact Sheet with you.
WORKPLACE EXPOSURE LIMITS
No occupational exposure limits have been established for
Diepoxybutane. This does not mean that this substance is not
harmful. Safe work practices should always be followed.
It should be recognized that Diepoxybutane can be absorbed through
you skin, thereby increasing you exposure.
* Diepoxybutane may be a CARCINOGEN in humans. There may be no
safe level of exposure to a carcinogen, so all contact should
be reduced to the lowest possible level.
WAYS OF REDUCING EXPOSURE
* Where possible, enclose operations and use local exhaust
ventilation at the site of chemical release. If local exhaust
ventilation or enclosure is not used, respirators should be
worn.
* Wear protective work clothing.
* Wash thoroughly immediately after exposure to Diepoxybutane
and at the end of the workshift.
* Post hazard and warning information in the work area. In
addition, as part of an ongoing education and training effort,
communicate all information on the health and safety hazards
of Diepoxybutane to potentially exposed workers.
This Fact Sheet is a summary source of information of all potential
and most severe health hazards that may result from exposure.
Duration of exposure, concentration of the substance and other
factors will affect your susceptibility to any of the potential
effects described below.
HEALTH HAZARD INFORMATION
Acute Health Effects
The following acute (short-term) health effects may occur
immediately or shortly after exposure to Diepoxybutane:
* Contact can severely irritate and burn the skin with
blistering.
* Contact can severely irritate and burn the eyes with possible
permanent damage.
* Breathing Diepoxybutane can irritate the nose, throat and
lungs causing a cough. Higher exposures may cause a build-up
of fluid in the lungs (pulmonary edema), a medical emergency.
Chronic Health Effects
The following chronic (long-term) health effects can occur at some
time after exposure to Diepoxybutane and can last for months or
years:
Cancer Hazard
* Diepoxybutane may be a CARCINOGEN in humans since it has been
show to cause skin cancer in animals.
* Many scientists believe there is no safe level of exposure to
a carcinogen. Such substances may also have the potential for
causing reproductive damage in humans.
Reproductive Hazard
* According to the information presently available,
Diepoxybutane has not been tested for its ability to affect
reproduction.
Other Long-Term Effects
* Diepoxybutane may damage the liver.
* It may affect the nervous system.
MEDICAL
MEDICAL TESTING
If symptoms develop or overexposure is suspected, the following may
be useful:
* Consider chest x-ray after acute over-exposure.
* Liver function test.
* Exam of the nervous system.
Any evaluation should include a careful history of past and present
symptoms with an exam. Medical test that look for damage already
done are not a substitute for controlling exposure.
Request copies of your medical testing. You have a legal right to
this information under OSHA 1910.20.
MIXED EXPOSURES
Because smoking can cause heart disease, as well as lung cancer,
emphysema, and other respiratory problems, it may worsen
respiratory conditions caused by chemical exposure. Even if you
have smoked for a long time, stopping now will reduce your risk of
developing health problems.
WORKPLACE CONTROLS AND PRACTICES
Unless a less toxic chemical can be substituted for a hazardous
substance, ENGINEERING CONTROLS are the most effective way of
reducing exposure. The best protection is to enclose operations
and/or provide local exhaust ventilation at the site of chemical
release. Isolating operations can also reduce exposure. Using
respirators or protective equipment is less effective than the
controls mentioned above, but is sometimes necessary.
In evaluating the controls present in your workplace, consider: (1)
how hazardous the substance is, (2) how much of the substance is
released into the workplace and (3) whether harmful skin or eye
contact could occur. Special controls should be in lace for highly
toxic chemicals or when significant skin, eye, or breathing
exposures are possible.
In addition, the following controls are recommended:
* Where possible, automatically transfer Diepoxybutane from
drums or other storage containers to process containers.
Good WORK PRACTICES can help to reduce hazardous exposures. The
following work practices are recommended:
* Workers whose clothing has been contaminated by Diepoxybutane
should change into clean clothing promptly.
* Contaminated work clothes should be laundered by individuals
who have been informed of the hazards of exposure to
Diepoxybutane.
* Eye wash fountains should be provided in the immediate work
area for emergency use.
* I there is the possibility of skin exposure, emergency shower
facilities should be provided.
* On skin contact with Diepoxybutane, immediately wash or shower
to remove the chemical. At the end of the workshift, wash any
areas of the body that may have contacted Diepoxybutane,
whether or not known skin contact has occurred.
* Do not eat, smoke, or drink where Diepoxybutane is handled,
processed, or stored, since the chemical can be swallowed.
Wash hands carefully before eating or smoking.
* Use a vacuum or a wet method to reduce dust during clean-up.
DO NOT DRY SEEP.
PERSONAL PROTECTIVE EQUIPMENT
WORKPLACE CONTROLS ARE BETTER THAN PERSONAL PROTECTIVE EQUIPMENT.
However, for some jobs (such as outside work, confined space entry,
jobs done only once in a while, or jobs done while workplace
controls are being installed), personal protective equipment may be
appropriate.
The following recommendations are only guidelines and may not apply
to every situation.
Clothing
* Avoid skin contact with Diepoxybutane. Wear protective gloves
and clothing. Safety equipment suppliers/manufacturers can
provide recommendations on the most protective glove/clothing
material for your operation.
* All protective clothing (suits, gloves, footwear, headgear)
should be clean, available each day, and put on before work.
Eye Protection
* Wear dust-proof goggles and face shield when working with
powders of dust, unless full facepiece respiratory protective
is worn.
* Wear splash-proof chemical goggles and face shield when
working with liquid, unless full facepiece respiratory
protection is worn.
Respiratory Protection
IMPROPER USE OF RESPIRATORS IS DANGEROUS. Such equipment should
only be used if the employer has a written program that takes into
account workplace conditions, requirements for worker training,
respirator fit testing and medical exams, as described in OSHA
1910.134.
* Engineering controls must be effective to ensure that exposure
to Diepoxybutane does not occur.
* Where the potential exists for exposure to Diepoxybutane, use
a MSHA/NIOSH approved supplied-air respirator with a full
facepiece operated in the positive pressure mode or with a
full facepiece, hood, or helmet in the continuous flow mode,
or use a MSHA/NIOSH approved self-contained breathing
apparatus with a full facepiece operated in pressure-demand or
other positive pressure mode.
HANDLING AND STORAGE
* Prior to working with Diepoxybutane you should be trained on
its proper handling and storage.
* Store in tightly closed containers in a cool, well-ventilated
area.
Common Name: Diepoxybutane
DOT Number : NA 1955
DOT Emergency Guide code: 15
CAS Number: 1464-53-5
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Hazard rating NJDOH NFPA
Flammability Not Found Not Rated
Reactivity Not Found Not Rated
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CARCINOGEN POISONOUS GASES ARE PRODUCED IN FIRE
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Hazard Rating Key: 0=minimal; 1=slight; 2=moderate; 3=serious;
4=severe
FIRE HAZARDS
* Diepoxybutane is COMBUSTIBLE.
* POISONOUS GASES ARE PRODUCED IN FIRE.
* If employees are expected to fight fires, they must be trained
and equipped as stated in OSHA 1910.156.
SPILLS AND EMERGENCIES
If Diepoxybutane is spilled, take the following steps:
* Restrict persons not wearing protective equipment from area of
spill until clean-up is complete.
* Remove all ignition sources.
* Ventilate area of spill or leak, after clean-up is complete.
* Absorb liquids in vermiculite, dry sand, earth, or a similar
material and deposit in sealed containers.
* Collect powdered material in the most convenient and safe
manner and deposit in sealed containers.
* It may be necessary to contain and dispose of Diepoxybutane as
a HAZARDOUS WASTE. Contact your state Environmental Program
for specific recommendations.
=============================================
FOR LARGE SPILLS AND FIRES immediately call your fire department.
=============================================
FIRST AID
POISON INFORMATION
Eye Contact
* Immediately flush with large amounts of water. Continue
without stopping for at least 30 minutes, occasionally
lifting upper and lower lids. Seek medical attention
immediately.
Skin Contact
* Quickly remove contaminated clothing. Immediately wash area
with large amounts of soap. Seek medical attention
immediately.
Breathing
* Remove the person from exposure.
* Begin rescue breathing if breathing has stopped and CPR if
heart action has stopped.
* Transfer promptly to a medical facility.
* Medical observation is recommended for 24 to 48 hours after
breathing overexposure, as pulmonary edema may be delayed.
PHYSICAL DATA
Water Solubility: Miscible
OTHER COMMONLY USED NAMES
Chemical Name:
2,2'-Bioxirane
Other Names and Formulations:
Diepoxybutane; DEB; Butadiene Diepoxide; Butadiene Dioxide.
This fact sheet can be used for the following isomers of
Diepoxybutane:
CAS # Common Name:
298-18-0 (+ -) Diepoxybutane
564-00-1 meso-Diepoxybutane
30419-67-1 D-Diepoxybutane
30031-64-2 L-Diepoxybutane
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Not intended to be copied and sold for commercial purposes.
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NEW JERSEY DEPARTMENT OF HEALTH
Right to Know Program
CN 368, Trenton, NJ 08625-0368
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ECOLOGICAL INFORMATION
Diepoxybutane is used for curing polymers and crosslinking textile
fibers. It is used as an agent to prevent microbial spoilage.
Diepoxybutane most likely enters the environment from industrial
discharges or spills.
ACUTE (SHORT-TERM) ECOLOGICAL EFFECTS
Acute toxic effects may include the death of animals, birds, or
fish and death or low growth rate of plants. Acute effects are
seen two to four days after animals or plants come in contact with
a toxic chemical substance.
Insufficient data are available to evaluate or predict the acute
(short-term) effects of Diepoxybutane to aquatic life, plants,
birds, or land animals.
CHRONIC (LONG-TERM) ECOLOGICAL EFFECTS
Chronic toxic effects may include shortened lifespan, reproductive
problems, lower fertility, and changes in appearance or behavior.
Chronic effects can be seen long after first exposure(s) to a toxic
chemical.
Insufficient data are available to evaluate or predict the chronic
(long-term) effects of Diepoxybutane to aquatic life, plants,
birds, or land animals.
WATER SOLUBILITY
Diepoxybutane is highly soluble in water. Concentrations of 1,000
milligrams and more will mix with a liter of water.
DISTRIBUTION AND PERSISTENCE IN THE ENVIRONMENT
Diepoxybutane is slightly persistent in water, with a half-life of
between 2 to 20 days. The half-life of a pollutant is the amount
of time it takes for one-half of the chemical to be degraded.
About 99.7% of Diepoxybutane will eventually end up in water; the
rest will end up in the air.
BIOACCUMULATION IN AQUATIC ORGANISMS
Some substances increase in concentration, or bioaccumulate, in
living organisms as they breathe contaminated air, drink
contaminated water, or eat contaminated food. These chemicals can
become concentrated in the tissues and internal organs of animals
and humans.
The concentration of Diepoxybutane found in fish tissues is
expected to be about the same as the average concentration of
Diepoxybutane in the water from which the fish was taken.
SUPPORT DOCUMENT: AQUIRE Database, ERL-Duluth, U.S. EPA.
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