Common Name: 4,4'-Methylenebis (n,n-Dimethyl) Benzenamine
CAS Number: 101-61-1
DOT Number: None
Date: August, 1987
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HAZARD SUMMARY
* 4,4'-Methylenebis (n,n-Dimethyl) Benzenamine can affect you
when breathed in and by passing through your skin.
* 4,4'-Methylenebis (n,n-Dimethyl) Benzenamine is a CARCINOGEN--
HANDLE WITH EXTREME CAUTION.
* High exposure can interfere with the ability of the blood to
carry oxygen (a condition called methemoglobinemia). This can
cause headaches, dizziness, weakness and a bluish color to the
skin and lips. Higher levels can cause trouble breathing,
collapse and death.
IDENTIFICATION
4,4'-Methylenebis (n,n-Dimethyl) Benzenamine is a crystalline
compound. It is used in dye manufacture and as an analytical
reagent for Lead.
REASON FOR CITATION
* 4,4'-Methylenebis (n,n-Dimethyl) Benzenamine is on the
Workplace Hazardous Substance List because it is cited by NTP
and DEP.
* This chemical is on the Special Health Hazard Substance List
because it is a CARCINOGEN and a MUTAGEN.
HOW TO DETERMINE IF YOU ARE BEING EXPOSED
* Exposure to hazardous substances should be routinely
evaluated. This may include collecting personal and area air
samples. You can obtain copies of sampling results from your
employer. You have a legal right to this information under
OSHA 1910.20.
* If you think you are experiencing any work-related health
problems, see a doctor trained to recognize occupational
diseases. Take this Fact Sheet with you.
-----------------------------------------
WORKPLACE EXPOSURE LIMITS
No occupational exposure limits have been established for 4,4'-
Methylenebis (n,n-Dimethyl) Benzenamine. This does not mean that
this substance is not harmful. Safe work practices should always be
followed.
It should be recognized that 4,4'-Methylenebis (n,n-Dimethyl)
Benzenamine can be absorbed through your skin, thereby increasing
your exposure.
* 4,4'-Methylenebis (n,n-Dimethyl) Benzenamine is a PROBABLE
CARCINOGEN in humans. There may be no safe level of exposure
to a carcinogen, so all contact should be reduced to the
lowest possible level.
WAYS OF REDUCING EXPOSURE
* Where possible, enclose operations and use local exhaust
ventilation at the site of chemical release. If local exhaust
ventilation or enclosure is not used, respirators should be
worn.
* Wear protective work clothing.
* Wash thoroughly immediately after exposure to 4,4'-
Methylenebis (n,n-Dimethyl) Benzenamine and at the end of the
workshift.
* Post hazard and warning information in the work area. In
addition, as part of an ongoing education and training effort,
communicate all information on the health and safety hazards
of 4,4'-Methylenebis (n,n-Dimethyl) Benzenamine to potentially
exposed workers.
This Fact Sheet is a summary source of information of all potential
and most severe health hazards that may result from exposure.
Duration of exposure, concentration of the substance and other
factors will affect your susceptibility to any of the potential
effects described below.
------------------------------------------
HEALTH HAZARD INFORMATION
Acute Health Effects
The following acute (short term) health effects may occur
immediately or shortly after exposure to 4,4'-Methylenebis (n,n-
Dimethyl) Benzenamine:
* High exposures, from either skin contact or breathing, can
interfere with the ability of the blood to carry oxygen. This
can cause headaches, dizziness, weakness, nausea and a bluish
color to the skin and lips. Still higher exposures can cause
trouble breathing, collapse and even death.
Chronic Health Effects
The following chronic (long term) health effects can occur at some
time after exposure to 4,4'-Methylenebis (n,n-Dimethyl) Benzenamine
and can last for months or years:
Cancer Hazard
* 4,4'-Methylenebis (n,n-Dimethyl) Benzenamine is a PROBABLE
CARCINOGEN in humans. It has been shown to cause liver and
thyroid cancer in animals.
* Many scientists believe there is no safe level of exposure to
a carcinogen. Such substances may also have the potential for
causing reproductive damage in humans.
Reproductive Hazard
* According to the information presently available to the New
Jersey Department of Health, 4,4'-Methylenebis (n,n-Dimethyl)
Benzenamine has not been tested for its ability to affect
reproduction.
Other Long Term Effects
* Some related (aniline-type) chemicals can cause skin allergy.
Once allergy develops, even low future exposures can trigger
rash and itching. It is not known whether 4,4'-Methylenebis
(n,n-Dimethyl) Benzenamine has this effect.
* Other long term effects are unknown at this time.
MEDICAL
Medical Testing
If symptoms develop or overexposure is suspected, the following may
be useful:
* Blood test for methemoglobin.
Any evaluation should include a careful history of past and present
symptoms with an exam. Medical tests that look for damage already
done are not a substitute for controlling exposure.
Request copies of your medical testing. You have a legal right to
this information under OSHA 1910.20.
WORKPLACE CONTROLS AND PRACTICES
Unless a less toxic chemical can be substituted for a hazardous
substance, ENGINEERING CONTROLS are the most effective way of
reducing exposure. The best protection is to enclose operations
and/or provide local exhaust ventilation at the site of chemical
release. Isolating operations can also reduce exposure. Using
respirators or protective equipment is less effective than the
controls mentioned above, but is sometimes necessary.
In evaluating the controls present in your workplace, consider: (1)
how hazardous the substance is, (2) how much of the substance is
released into the workplace and (3) whether harmful skin or eye
contact could occur. Special controls should be in place for highly
toxic chemicals or when significant skin, eye, or breathing
exposures are possible.
In addition, the following control is recommended:
* Where possible, automatically transfer 4,4'-Methylenebis (n,n-
Dimethyl) Benzenamine from drums or other storage containers
to process containers.
Good WORK PRACTICES can help to reduce hazardous exposures. The
following work practices are recommended:
* Workers whose clothing has been contaminated by 4,4'-
Methylenebis (n,n-Dimethyl) Benzenamine should change into
clean clothing promptly.
* Contaminated work clothes should be laundered by individuals
who have been informed of the hazards of exposure to 4,4'-
Methylenebis (n,n-Dimethyl) Benzenamine.
* On skin contact with 4,4'-Methylenebis (n,n-Dimethyl)
Benzenamine, immediately wash or shower to remove the
chemical. At the end of the workshift, wash any areas of the
body that may have contacted 4,4'-Methylenebis (n,n-Dimethyl)
Benzenamine, whether or not known skin contact has occurred.
* Do not eat, smoke, or drink where 4,4'-Methylenebis (n,n-
Dimethyl) Benzenamine is handled, processed, or stored, since
the chemical can be swallowed. Wash hands carefully before
eating or smoking.
* Use a vacuum or a wet method to reduce dust during clean-up.
Do not dry sweep.
* When vacuuming, a high efficiency particulate absolute (HEPA)
filter should be used, not a standard shop vacuum.
PERSONAL PROTECTIVE EQUIPMENT
WORKPLACE CONTROLS ARE BETTER THAN PERSONAL PROTECTIVE EQUIPMENT.
However, for some jobs (such as outside work, confined space entry,
jobs done only once in a while, or jobs done while workplace
controls are being installed), personal protective equipment may be
appropriate.
The following recommendations are only guidelines and may not apply
to every situation.
Clothing
* Avoid skin contact with 4,4'-Methylenebis (n,n-Dimethyl)
Benzenamine. Wear protective gloves and clothing. Safety
equipment suppliers/manufacturers can provide recommendations
on the most protective glove/clothing material for your
operation.
* All protective clothing (suits, gloves, footwear, headgear)
should be clean, available each day and put on before work.
Eye Protection
* Eye protection is included in the recommended respiratory
protection.
Respiratory Protection
IMPROPER USE OF RESPIRATORS IS DANGEROUS. Such equipment should
only be used if the employer has a written program that takes into
account workplace conditions, requirements for worker training,
respirator fit testing and medical exams, as described in OSHA
1910.134.
* Engineering controls must be effective to ensure that exposure
to 4,4'-Methylenebis (n,n-Dimethyl) Benzenamine does not
occur.
* At any exposure level, use a MSHA/NIOSH approved supplied-air
respirator with a full facepiece operated in the positive
pressure mode or with a full facepiece, hood, or helmet in the
continuous flow mode, or use a MSHA/NIOSH approved self-
contained breathing apparatus with a full facepiece operated
in pressure-demand or other positive pressure mode.
Common Name: 4,4'-methylenebis (n,n-Dimethyl) Benzenamine
DOT Number: None
DOT Emergency Guide code: No Citation
CAS Number: 101-61-1
-----------------------------------------
Hazard rating NFPA
FLAMMABILITY Not Rated
REACTIVITY Not Rated
-----------------------------------------
POISONOUS GASES ARE PRODUCED IN FIRE
-----------------------------------------
Hazard Rating Key: 0=minimal; 1=slight; 2=moderate; 3=serious;
4=severe
FIRE HAZARDS
* POISONOUS GASES ARE PRODUCED IN FIRE, including Nitrogen
Oxides.
* If employees are expected to fight fires, they must be trained
and equipped as stated in OSHA 1910.156.
SPILLS AND EMERGENCIES
If 4,4'-Methylenebis (n,n-Dimethyl) Benzenamine is spilled, take
the following steps:
* Restrict persons not wearing protective equipment from area of
spill until clean-up is complete.
* Collect powdered material in the most convenient and safe
manner and deposit in sealed containers.
* It may be necessary to contain and dispose of 4,4'-
Methylenebis (n,n-Dimethyl) Benzenamine as a HAZARDOUS WASTE.
Contact your Department of Environmental Protection (DEP) or
your regional office of the federal Environmental Protection
Agency (EPA) for specific recommendations.
==========================================
FOR LARGE SPILLS AND FIRES immediately call your fire department.
==========================================
HANDLING AND STORAGE
* Prior to working with 4,4'-Methylenebis (n,n-Dimethyl)
Benzenamine you should be trained on its proper handling and
storage.
* 4,4'-Methylenebis (n,n-Dimethyl) Benzenamine must be stored to
avoid contact with OXIDIZERS (such as PERCHLORATES, PEROXIDES,
PERMANGANATES, CHLORATES and NITRATES) and STRONG ACIDS (such
as HYDROCHLORIC, SULFURIC and NITRIC) since violent reactions
occur.
* Store in tightly closed containers in a cool, well-ventilated
area.
* A regulated, marked area should be established where 4,4'-
Methylenebis (n,n-Dimethyl) Benzenamine is handled, used, or
stored.
FIRST AID
Eye Contact
* Immediately flush with large amounts of water for at least 15
minutes, occasionally lifting upper and lower lids.
Skin Contact
* Quickly remove contaminated clothing. Immediately wash
contaminated skin with large amounts of soap and water.
If Symptoms Develop
* Remove the person from exposure.
* Begin rescue breathing if breathing has stopped and CPR if
heart action has stopped.
* Transfer promptly to a medical facility.
PHYSICAL DATA
Water Solubility: Insoluble
OTHER COMMONLY USED NAMES
Chemical Name:
Aniline,4,4'-Methylene-bis(n,n-Dimethyl)-
Other Names and Formulations:
Michler's Base; Methane Base Michler's Hydride; Michler's Methane;
Tetra Base.
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Not intended to be copied and sold for commercial purposes.
------------------------------------------
NEW JERSEY DEPARTMENT OF HEALTH
Right to Know Program
CN 368, Trenton, NJ 08625-0368
(609) 984-2202
------------------------------------------
------------------------------------------
ECOLOGICAL INFORMATION
4,4'-Methylenebis (n,n-Dimethyl) Benzenamine is a solid chemical
which is used in the form of the hydrochloride as a reagent for
lead. It may enter the environment from industrial discharges or
spills.
ACUTE (SHORT-TERM) ECOLOGICAL EFFECTS
Acute toxic effects may include the death of animals, birds, or
fish, and death or low growth rate in plants. Acute effects are
seen two to four days after animals or plants come in contact with
a toxic chemical substance.
4,4'-Methylenebis (n,n-Dimethyl) Benzenamine has high acute
toxicity to aquatic life. Insufficient data are available to
evaluate or predict the short-term effects of this chemical to
plants, birds, or land animals.
CHRONIC (LONG-TERM) ECOLOGICAL EFFECTS
Chronic toxic effects may include shortened lifespan, reproductive
problems, lower fertility, and changes in appearance or behavior.
Chronic effects can be seen long after first exposure(s) to a toxic
chemical.
4,4'-Methylenebis (n,n-Dimethyl) Benzenamine has high chronic to
aquatic life. Insufficient data are available to evaluate or
predict the long-term effects of this chemical to plants, birds, or
land animals.
WATER SOLUBILITY
4,4'-Methylenebis (n,n-Dimethyl) Benzenamine is moderately soluble
in water. Concentrations of between 1 to 1,000 milligrams will mix
with a liter of water.
DISTRIBUTION AND PERSISTENCE IN THE ENVIRONMENT
4,4'-Methylenebis (n,n-Dimethyl) Benzenamine is moderately
persistent in water, with a half-life of between 20 to 200 days.
The half-life of a pollutant is the amount of time it takes for
one-half of the chemical to be degraded. About 46.3% of this
chemical will eventually end up in terrestrial soil; about 43.2% in
aquatic sediments; the rest will end up in the water.
BIOACCUMULATION IN AQUATIC ORGANISMS
Some substances increase in concentration, or bioaccumulate, in
living organisms as they breathe contaminated air, drink
contaminated water, or eat contaminated food. These chemicals can
become concentrated in the tissues and internal organs of animals
and humans.
The concentration of 4,4'-Methylenebis (n,n-Dimethyl) Benzenamine
found in fish tissues is expected to be much higher than the
average concentration of this chemical in the water from which the
fish was taken.
SUPPORT DOCUMENT: AQUIRE Database, ERL-Duluth, U.S. EPA.
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