Common Name: 4,4'-Methylenebis (2-Chloroaniline)
CAS Number: 101-14-4
DOT Number: None
Date: January 31, 1986
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HAZARD SUMMARY
* 4,4'-Methylenebis (2-Chloroaniline) can affect you when
breathed in and by passing through your skin.
* 4,4'-Methylenebis (2-Chloroaniline) is a CARCINOGEN HANDLE
WITH EXTREME CAUTION.
* Exposure can interfere with the ability of the blood to carry
oxygen causing headaches, dizziness, nausea and a bluish color
to the skin and lips. High levels can cause trouble breathing,
collapse and death.
* Contact can irritate the eyes.
* High or repeated exposures may affect the kidneys, cause a low
blood count and cause bloody urine.
IDENTIFICATION
4,4'-Methylenebis (2-Chloroaniline) is found as a tan colored
solid. It is used in manufacture of polyurethanes and epoxy resins.
REASON FOR CITATION
* 4,4'-Methylenebis (2-Chloroaniline) is on the Hazardous
Substance List because it is regulated by OSHA and cited by
ACGIH, NIOSH, NTP, CAG and DEP.
* This chemical is on the Special Health Hazard Substance List
because it is a CARCINOGEN.
* Definitions are attached.
HOW TO DETERMINE IF YOU ARE BEING EXPOSED
* Exposure to hazardous substances should be routinely
evaluated. This may include collecting personal and area air
samples. You can obtain copies of sampling results from your
employer. You have a legal right to this information under
OSHA 1910.20.
* If you think you are experiencing any work related health
problems, see a doctor trained to recognize occupational
diseases. Take this Fact Sheet with you.
WORKPLACE EXPOSURE LIMITS
OSHA: Standard formally revoked in 1975.
NIOSH: The recommended airborne exposure limit is 0.003 mg/m3
averaged over a 10 hour workshift (lowest detectable
level).
ACGIH: The recommended airborne exposure limit is 0.22 mg/m3
averaged over an 8 hour workshift.
* 4,4'-Methylenebis (2-Chloroaniline) is a PROBABLE CARCINOGEN
in humans. There may be no safe level of exposure to a
carcinogen, so all contact should be reduced to the lowest
possible level.
WAYS OF REDUCING EXPOSURE
* Where possible, enclose operations and use local exhaust
ventilation at the site of chemical release. If local exhaust
ventilation or enclosure is not used, respirators should be
worn.
* A regulated, marked area should be established where 4,4'-
Methylenebis (2-Chloroaniline) is handled, used, or stored.
* Wear protective work clothing.
* Wash thoroughly immediately after exposure to 4,4'-
Methylenebis (2-Chloroaniline) and at the end of the
workshift.
* Post hazard and warning information in the work area. As part
of an ongoing education and training effort, communicate all
information on the health and safety hazards of 4,4'-
Methylenebis (2-Chloroaniline) to potentially exposed workers.
This Fact Sheet is a summary source of information for workers,
employers and community residents. Health professionals may also
find it useful. If this substance is part of a mixture, this Fact
Sheet should be used along with the manufacturer supplied Material
Safety Data Sheet (MSDS).
HEALTH HAZARD INFORMATION
Acute Health Effects
The following acute (short term) health effects may occur
immediately or shortly after exposure to 4,4'-Methylenebis (2-
Chloroaniline):
* Exposure can interfere with the ability of the blood to carry
oxygen (a condition called methemoglobinemia). This can cause
headaches, dizziness, nausea and a bluish color to the skin
and lips. Higher levels can cause trouble breathing, collapse
and even death.
* Contact can irritate the eyes.
Chronic Health Effects
The following chronic (long term) health effects can occur at some
time after exposure to 4,4'-Methylenebis (2-Chloroaniline) and can
last for months or years:
Cancer Hazard
* 4,4'-Methylenebis (2-Chloroaniline) is a PROBABLE CARCINOGEN
in humans. There is some evidence that it causes lung, liver
and bladder cancer in animals.
* Many scientists believe there is no safe level of exposure to
a carcinogen. Such substances may also have the potential for
causing reproductive damage in humans.
Reproductive Hazard
* According to the information presently available to the New
Jersey Department of Health, 4,4'-Methylenebis (2-
Chloroaniline) has not been tested for its ability to
adversely affect reproduction.
Other Long Term Effects
* High or repeated exposures may damage the kidneys and can
cause bloody urine.
* 4,4'-Methylenebis (2-Chloroaniline) may cause a low blood
count.
MEDICAL TESTING
If symptoms develop or overexposure is suspected, the following may
be useful:
* Blood methemoglobin level.
* Complete blood count.
* Kidney function tests.
Any evaluation should include a careful history of past and present
symptoms with an exam. Medical tests that look for damage already
done are not a substitute for controlling exposure.
Request copies of your medical testing. You have a legal right to
this information under OSHA 1910.20.
WORKPLACE CONTROLS AND PRACTICES
Unless a less toxic chemical can be substituted for a hazardous
substance, ENGINEERING CONTROLS are the most effective way of
reducing exposure. The best protection is to enclose operations
and/or provide local exhaust ventilation at the site of chemical
release. Isolating operations can also reduce exposure. Using
respirators or protective equipment is less effective than the
controls mentioned above, but is sometimes necessary.
In evaluating the controls present in your workplace, consider: (1)
how hazardous the substance is, (2) how much of the substance is
released into the workplace and (3) whether harmful skin or eye
contact could occur. Special controls should be in place for highly
toxic chemicals or when significant skin, eye, or breathing
exposures are possible.
In addition, the following control is recommended:
* Where possible, automatically transfer 4, 4'Methylenebis (2
Chloroaniline) from drums or other storage containers to
process containers.
Good WORK PRACTICES can help to reduce hazardous exposures. The
following work practices are recommended:
* Workers whose clothing has been contaminated by 4,4'-
Methylenebis (2-Chloroaniline) should change into clean
clothing promptly.
* Do not take contaminated work clothes home. Family members
could be exposed.
* Contaminated work clothes should be laundered by individuals
who have been informed of the hazards of exposure to 4,4'-
Methylenebis (2-Chloroaniline).
* If there is the possibility of skin exposure, emergency shower
facilities should be provided.
* On skin contact with 4,4'-Methylenebis (2-Chloroaniline),
immediately wash or shower to remove the chemical. At the end
of the workshift, wash any areas of the body that may have
contacted 4,4'-Methylenebis (2-Chloroaniline), whether or not
known skin contact has occurred.
* Do not eat, smoke, or drink where 4,4'-Methylenebis (2-
Chloroaniline) is handled, processed, or stored, since the
chemical can be swallowed. Wash hands carefully before eating
or smoking.
* Use a vacuum or a wet method to reduce dust during clean up.
DO NOT DRY SWEEP.
* When vacuuming, a high efficiency particulate absolute (HEPA)
filter should be used, not a standard shop vacuum.
PERSONAL PROTECTIVE EQUIPMENT
WORKPLACE CONTROLS ARE BETTER THAN PERSONAL PROTECTIVE EQUIPMENT.
However, for some jobs (such as outside work, confined space entry,
jobs done only once in a while, or jobs done while workplace
controls are being installed), personal protective equipment may be
appropriate.
The following recommendations are only guidelines and may not apply
to every situation.
Clothing
* Avoid skin contact with 4,4'-Methylenebis (2-Chloroaniline).
Wear protective gloves and clothing. Safety equipment
suppliers/manufacturers can provide recommendations on the
most protective glove/clothing material for your operation.
* All protective clothing (suits, gloves, footwear, headgear)
should be clean, available each day and put on before work.
Eye Protection
* Eye protection is included in the recommended respiratory
protection.
Respiratory Protection
IMPROPER USE OF RESPIRATORS IS DANGEROUS. Such equipment should
only be used if the employer has a written program that takes into
account workplace conditions, requirements for worker training,
respirator fit testing, and medical exams, as described in OSHA
1910.134.
* At any exposure level, use a MSHA/NIOSH approved supplied air
respirator with a full facepiece operated in the positive
pressure mode or with a full facepiece, hood, or helmet in the
continuous flow mode, or use a MSHA/NIOSH approved self
contained breathing apparatus with a full facepiece operated
in pressure demand or other positive pressure mode.
HANDLING AND STORAGE
* Prior to working with 4,4'-Methylenebis (2-Chloroaniline) you
should be trained on its proper handling and storage.
* 4,4'-Methylenebis (2-Chloroaniline) must be stored to avoid
contact with CHEMICALLY ACTIVE METALS (such as POTASSIUM,
SODIUM, MAGNESIUM and ZINC) since violent reactions occur.
* Store in tightly closed containers in a cool, well ventilated
area.
* A regulated, marked area should be established where 4,4'-
Methylenebis (2-Chloroaniline) is handled, used, or stored.
Common Name: 4,4'-Methylenebis (2-Chloroaniline)
DOT Number: None
DOT Emergency Guide code: No Citation
CAS Number: 101-14-4
----------------------------------------
NJ DOH Hazard rating
FLAMMABILITY not found
REACTIVITY not found
----------------------------------------
POISONOUS GASES ARE PRODUCED IN FIRE
----------------------------------------
Hazard Rating Key: 0=minimal; 1=slight; 2=moderate; 3=serious;
4=severe
FIRE HAZARDS
* Use dry chemical, CO2, water spray, or foam extinguishers.
* POISONOUS GASES ARE PRODUCED IN FIRE, including Chlorine and
Nitrogen oxides.
* If employees are expected to fight fires, they must be trained
and equipped as stated in OSHA 1910.156.
SPILLS AND EMERGENCIES
If 4,4'-Methylenebis (2-Chloroaniline) is spilled, take the
following steps:
* Restrict persons not wearing protective equipment from area of
spill until cleanup is complete.
* Collect powdered material in the most convenient and safe
manner and deposit in sealed containers.
* It may be necessary to contain and dispose of 4,4'-
Methylenebis (2-Chloroaniline) as a HAZARDOUS WASTE. Contact
your state Environmental Program for specific recommendations.
==========================================
FOR LARGE SPILLS AND FIRES immediately call your fire department.
==========================================
FIRST AID
POISON INFORMATION
Eye Contact
* Immediately flush with large amounts of water for at least 15
minutes, occasionally lifting upper and lower lids.
Skin Contact
* Quickly remove contaminated clothing. Immediately wash
contaminated skin with large amounts of soap and water.
If Symptoms Develop
* Remove the person from exposure.
* Begin rescue breathing if breathing has stopped and CPR if
heart action has stopped.
PHYSICAL DATA
Vapor Pressure: Less than 0.00001 mm Hg at 68oF
Water Solubility: Slightly soluble
OTHER COMMONLY USED NAMES
Chemical Name:
Benzenamine, 4,4' Methylenebis 2 Chloro
Other Names and Formulations:
BOCA; Bis Amine; Cyanaset; DACPM; MOCA.
------------------------------------------
Not intended to be copied and sold for commercial purposes.
------------------------------------------
NEW JERSEY DEPARTMENT OF HEALTH
Right to Know Program
CN 368, Trenton, NJ 08625 0368
-----------------------------------------
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ECOLOGICAL INFORMATION
4,4'-Methylenebis (2-Chloroaniline) is a solid chemical used as a
curing agent for cross-linked thermoset polymers. It may enter the
environment from industrial effluents or spills.
ACUTE (SHORT-TERM) ECOLOGICAL EFFECTS
Acute toxic effects may include the death of animals, birds, or
fish, and death or low growth rate in plants. Acute effects are
seen two to four days after animals or plants come in contact with
a toxic chemical substance.
4,4'-Methylenebis (2-Chloroaniline) has high acute toxicity to
aquatic life. Insufficient data are available to evaluate or
predict the short-term effects of 4,4'-Methylenebis (2-
Chloroaniline) on plants, birds, or land animals.
CHRONIC (LONG-TERM) ECOLOGICAL EFFECTS
Chronic toxic effects may include shortened lifespan, reproductive
problems, lower fertility, and changes in appearance or behavior.
Chronic effects can be seen long after first exposure(s) to a toxic
chemical.
4,4'-Methylenebis (2-Chloroaniline) has high chronic toxicity to
aquatic life. Insufficient data are available to evaluate or
predict the long-term effects of 4,4'-Methylenebis (2-
Chloroaniline) on plants, birds, or land animals.
WATER SOLUBILITY
4,4'-Methylenebis (2-Chloroaniline) is moderately soluble in water.
Concentrations of between 1 to 1,000 milligrams will mix with a
liter of water.
DISTRIBUTION AND PERSISTENCE IN THE ENVIRONMENT
4,4'-Methylenebis (2-Chloroaniline) is moderately persistent in the
environment with a half-life of between 20 to 200 days. The half-
life of a pollutant is the amount of time it takes for one-half of
the chemical to be degraded. The chemical properties of 4,4'-
Methylenebis (2-Chloroaniline) indicate that about 43% will enter
the water, 28% aquatic sediments, and 30% terrestrial soil.
BIOACCUMULATION IN AQUATIC ORGANISMS
Some substances increase in concentration, or bioaccumulate, in
living organisms as they breathe contaminated air, drink
contaminated water, or eat contaminated food. These chemicals can
become concentrated in the tissues and internal organs of animals
and humans.
The concentration of 4,4'-Methylenebis (2-Chloroaniline) found in
fish tissues is expected to be somewhat higher than the average
concentration of 4,4'-Methylenebis (2-Chloroaniline) in the water
from which the fish was taken.
SUPPORT DOCUMENT: AQUIRE Database, ERL-Duluth, U.S. EPA.
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